Insulin Receptor signalling cascade
نویسندگان
چکیده
منابع مشابه
Lipid Microdomains in Insulin Receptor Signalling
9 REVIEW OF THE LITERATURE 11 1. Cell membranes and cholesterol 11 1.1 Cellular membranes 11 1.1.1 Basic structure and components 11 1.1.2 Cholesterol-sphingolipid interaction 14 1.1.3 Distribution of cholesterol and other lipids in cell membranes 15 1.2 Cholesterol homeostasis in mammalian cells 16 1.2.1 Cholesterol biosynthesis, lipoprotein uptake and cholesterol efflux 16 1.2.2 Cholesterol e...
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Insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) are highly conserved receptor tyrosine kinases that share signalling proteins and are ubiquitously expressed in the brain. Central application of insulin or IGF1 exerts several similar physiological outcomes, varying in strength, whereas disruption of the corresponding receptors in the brain leads to remarkably different ef...
متن کاملIκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.
In the present study, we have examined whether IKKβ [IκB (inhibitor of nuclear factor κB) kinase β] plays a role in feedback inhibition of the insulin signalling cascade. Insulin induces the phosphorylation of IKKβ, in vitro and in vivo, and this effect is dependent on intact signalling via PI3K (phosphoinositide 3-kinase), but not PKB (protein kinase B). To test the hypothesis that insulin act...
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Nitric oxide activates guanylate cyclase to form cGMP, comprising a signalling system that is believed to be a distinct mechanism for increasing glucose transport and metabolism in skeletal muscle. The effects of a selective cGMP phosphodiesterase inhibitor, zaprinast, on basal glucose utilization was investigated in incubated rat soleus muscle preparations isolated from both insulin-sensitive ...
متن کاملDirect Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene Loci
OBJECTIVE Insulin receptor (IR) translocates to the nucleus, but its recruitment to gene loci has not been demonstrated. Here, we tested the hypothesis that IR and its downstream mitogenic transducers are corecruited to two prototypic insulin-inducible genes: early growth response 1 (egr-1), involved in mitogenic response, and glucokinase (Gck), encoding a key metabolic enzyme. RESEARCH DESIG...
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ژورنال
عنوان ژورنال: Reactome - a curated knowledgebase of biological pathways
سال: 2008
ISSN: 1934-1792
DOI: 10.3180/react_1195.4